We study how a broad range of basic functional processes are modified, and potentially coordinated, to control cellular homeostasis. Our research primarily uses E. coli as a model, but the concepts will also be tested on pathogens such as Salmonella or Shigella. Focusing on two global cellular processes, Fe-S cluster biogenesis and lipid homeostasis, allows us to study the impact of stress on aerobic and anaerobic metabolism, cell envelope homeostasis and membrane, redox changes, nutrient limitation, metabolic stress and antibiotics.
Molecular, biochemical and genetic approaches, as well as cutting-edge technologies (-omics, imaging, single-cell analysis), aim to achieve an integrated and mechanistic vision of the bacterial cell. Multiplying and diversifying the ways of approaching a process is very rewarding, and we collaborate with biochemists, structuralists, chemists, biophysicists, bioinformaticians and phylogeneticists.